Title |
The mononuclear phagocyte system
|
---|---|
Published in |
Current Opinion in Immunology, December 2005
|
DOI | 10.1016/j.coi.2005.11.008 |
Pubmed ID | |
Authors |
David A Hume |
Abstract |
The mononuclear phagocyte system (MPS) has been defined as a family of cells comprising bone marrow progenitors, blood monocytes and tissue macrophages. Macrophages are a major cell population in most of the tissues in the body, and their numbers increase further in inflammation, wounding and malignancy. Their trophic roles for other cell types in development and homeostasis are becoming increasingly evident. The receptor for macrophage colony-stimulating factor (CSF-1R) is expressed in a large proportion of cells considered to be mononuclear phagocytes, including antigen-presenting dendritic cells, which can be considered a specialized adaptive state rather than a separate lineage. The unity of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, by the transdifferentiation and fusion of MPS cells with other cell types, and by evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. The concept of the MPS may have partly outlived its usefulness. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Comoros | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 8 | 1% |
United States | 5 | <1% |
Germany | 3 | <1% |
Australia | 2 | <1% |
Brazil | 2 | <1% |
Lithuania | 1 | <1% |
Colombia | 1 | <1% |
Spain | 1 | <1% |
Canada | 1 | <1% |
Other | 0 | 0% |
Unknown | 528 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 124 | 22% |
Researcher | 95 | 17% |
Student > Master | 80 | 14% |
Student > Bachelor | 63 | 11% |
Student > Doctoral Student | 25 | 5% |
Other | 69 | 13% |
Unknown | 96 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 164 | 30% |
Medicine and Dentistry | 85 | 15% |
Biochemistry, Genetics and Molecular Biology | 65 | 12% |
Immunology and Microbiology | 52 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 4% |
Other | 60 | 11% |
Unknown | 103 | 19% |