| Title |
Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury
|
|---|---|
| Published in |
Intensive Care Medicine, June 2012
|
| DOI | 10.1007/s00134-012-2610-4 |
| Pubmed ID | |
| Authors |
Spyridon Fortis, Peter M. Spieth, Wei-Yang Lu, Matteo Parotto, Jack J. Haitsma, Arthur S. Slutsky, Nanshan Zhong, C. David Mazer, Haibo Zhang |
| Abstract |
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter through activation of GABA receptors. Volatile anesthetics activate type-A (GABA(A)) receptors resulting in inhibition of synaptic transmission. Lung epithelial cells have been recently found to express GABA(A) receptors that exert anti-inflammatory properties. We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | 3% |
| France | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 55 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 17% |
| Other | 6 | 10% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Postgraduate | 6 | 10% |
| Student > Master | 6 | 10% |
| Other | 11 | 19% |
| Unknown | 14 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 54% |
| Agricultural and Biological Sciences | 5 | 8% |
| Nursing and Health Professions | 3 | 5% |
| Neuroscience | 2 | 3% |
| Psychology | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 12 | 20% |