| Title |
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice
|
|---|---|
| Published in |
Diabetologia, June 2012
|
| DOI | 10.1007/s00125-012-2600-7 |
| Pubmed ID | |
| Authors |
G. da Silva Xavier, A. Mondragon, G. Sun, L. Chen, J. A. McGinty, P. M. French, G. A. Rutter |
| Abstract |
Individuals carrying type 2 diabetes risk alleles in TCF7L2 display decreased beta cell levels of T cell factor 7 like-2 (TCF7L2) immunoreactivity, and impaired insulin secretion and beta cell sensitivity to glucagon-like peptide 1 (GLP-1). Here, we sought to determine whether selective deletion of Tcf7l2 in mouse pancreas impairs insulin release and glucose homeostasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Germany | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 67 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 23% |
| Student > Master | 8 | 11% |
| Researcher | 6 | 9% |
| Student > Bachelor | 5 | 7% |
| Professor > Associate Professor | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 29% |
| Agricultural and Biological Sciences | 17 | 24% |
| Medicine and Dentistry | 5 | 7% |
| Engineering | 2 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2012.
All research outputs
#18,309,495
of 22,669,724 outputs
Outputs from Diabetologia
#4,665
of 5,024 outputs
Outputs of similar age
#126,114
of 164,032 outputs
Outputs of similar age from Diabetologia
#32
of 50 outputs
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