Title |
Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway
|
---|---|
Published in |
Blood, June 2012
|
DOI | 10.1182/blood-2012-01-402404 |
Pubmed ID | |
Authors |
Siok-Keen Tey, Rajiv Khanna |
Abstract |
The endogenous presentation of the majority of viral epitopes through MHC class I pathway is strictly dependent on the transporter associated with antigen processing (TAP) complex, which transfers the peptide products of proteasomal degradation into the endoplasmic reticulum. A small number of epitopes can be presented through the TAP-independent pathway, the precise mechanism for which remains largely unresolved. Here we show that TAP-independent presentation can be mediated by autophagy and that this process uses the vacuolar pathway and not the conventional secretory pathway. After macroautophagy, the antigen is processed through a proteasome-independent pathway, and the peptide epitopes are loaded within the autophagolysosomal compartment in a process facilitated by the relative acid stability of the peptide-MHC interaction. Despite bypassing much of the conventional MHC class I pathway, the autophagy-mediated pathway generates the same epitope as that generated through the conventional pathway and thus may have a role in circumventing viral immune evasion strategies that primarily target the conventional pathway. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Russia | 1 | <1% |
Venezuela, Bolivarian Republic of | 1 | <1% |
Unknown | 102 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 28% |
Researcher | 15 | 14% |
Student > Master | 12 | 11% |
Student > Bachelor | 9 | 9% |
Student > Doctoral Student | 8 | 8% |
Other | 14 | 13% |
Unknown | 18 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 39 | 37% |
Biochemistry, Genetics and Molecular Biology | 20 | 19% |
Immunology and Microbiology | 14 | 13% |
Medicine and Dentistry | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 6 | 6% |
Unknown | 18 | 17% |