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A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers

Overview of attention for article published in Cancer Epidemiology, Biomarkers & Prevention, August 2012
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Title
A Nonsynonymous Polymorphism in IRS1 Modifies Risk of Developing Breast and Ovarian Cancers in BRCA1 and Ovarian Cancer in BRCA2 Mutation Carriers
Published in
Cancer Epidemiology, Biomarkers & Prevention, August 2012
DOI 10.1158/1055-9965.epi-12-0229
Pubmed ID
Authors

Yuan C. Ding, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani- Paluch–Shimon, Bella Kaufman, Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M. Domchek, Katherine L. Nathanson, Timothy R. Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Jacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Tomasz Byrski, Ana Osorio, Teresa Ramóny Cajal, Alexandra V. Stavropoulou, Javier Benítez, Ute Hamann, Matti Rookus, Cora M. Aalfs, Judith L. de Lange, Hanne E.J. Meijers-Heijboer, Jan C. Oosterwijk, Christi J. van Asperen, Encarna B. Gómez García, Nicoline Hoogerbrugge, Agnes Jager, Rob B. van der Luijt, Douglas F. Easton, Susan Peock, Debra Frost, Steve D. Ellis, Radka Platte, Elena Fineberg, D. Gareth Evans, Fiona Lalloo, Louise Izatt, Ros Eeles, Julian Adlard, Rosemarie Davidson, Diana Eccles, Trevor Cole, Jackie Cook, Carole Brewer, Marc Tischkowitz, Andrew K. Godwin, Harsh Pathak, Dominique Stoppa-Lyonnet, Olga M. Sinilnikova, Sylvie Mazoyer, Laure Barjhoux, Mélanie Léoné, Marion Gauthier-Villars, Virginie Caux-Moncoutier, Antoine de Pauw, Agnès Hardouin, Pascaline Berthet, Hélène Dreyfus, Sandra Fert Ferrer, Marie-Agnès Collonge-Rame, Johanna Sokolowska, Saundra Buys, Mary Daly, Alex Miron, Mary Beth Terry, Wendy Chung, Esther M. John, Melissa Southey, David Goldgar, Christian F. Singer, Muy-Kheng Maria Tea, Daphne Gschwantler-Kaulich, Anneliese Fink-Retter, Thomas V.O. Hansen, Bent Ejlertsen, Oskar T. Johannsson, Kenneth Offit, Kara Sarrel, Mia M. Gaudet, Joseph Vijai, Mark Robson, Marion R. Piedmonte, Lesley Andrews, David Cohn, Leslie R. DeMars, Paul DiSilvestro, Gustavo Rodriguez, Amanda Ewart Toland, Marco Montagna, Simona Agata, Evgeny Imyanitov, Claudine Isaacs, Ramunas Janavicius, Conxi Lazaro, Ignacio Blanco, Susan J. Ramus, Lara Sucheston, Beth Y. Karlan, Jenny Gross, Patricia A. Ganz, Mary S. Beattie, Rita K. Schmutzler, Barbara Wappenschmidt, Alfons Meindl, Norbert Arnold, Dieter Niederacher, Sabine Preisler-Adams, Dorotehea Gadzicki, Raymonda Varon-Mateeva, Helmut Deissler, Andrea Gehrig, Christian Sutter, Karin Kast, Heli Nevanlinna, Kristiina Aittomäki, Jacques Simard, Amanda B. Spurdle, Jonathan Beesley, Xiaoqing Chen, Gail E. Tomlinson, Jeffrey Weitzel, Judy E. Garber, Olufunmilayo I. Olopade, Wendy S. Rubinstein, Nadine Tung, Joanne L. Blum, Steven A. Narod, Sean Brummel, Daniel L. Gillen, Noralane Lindor, Zachary Fredericksen, Vernon S. Pankratz, Fergus J. Couch, Paolo Radice, Paolo Peterlongo, Mark H. Greene, Jennifer T. Loud, Phuong L. Mai, Irene L. Andrulis, Gord Glendon, Hilmi Ozcelik, Anne-Marie Gerdes, Mads Thomassen, Uffe Birk Jensen, Anne-Bine Skytte, Maria A. Caligo, Andrew Lee, Georgia Chenevix-Trench, Antonis C. Antoniou, Susan L. Neuhausen

Abstract

We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Netherlands 1 2%
Russia 1 2%
Unknown 58 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 13%
Researcher 8 13%
Professor > Associate Professor 5 8%
Professor 5 8%
Other 3 5%
Other 11 18%
Unknown 21 34%
Readers by discipline Count As %
Medicine and Dentistry 15 25%
Biochemistry, Genetics and Molecular Biology 10 16%
Agricultural and Biological Sciences 10 16%
Social Sciences 2 3%
Sports and Recreations 1 2%
Other 2 3%
Unknown 21 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2012.
All research outputs
#20,755,951
of 25,498,750 outputs
Outputs from Cancer Epidemiology, Biomarkers & Prevention
#3,857
of 4,854 outputs
Outputs of similar age
#145,248
of 184,674 outputs
Outputs of similar age from Cancer Epidemiology, Biomarkers & Prevention
#38
of 47 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,854 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,674 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.