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X Demographics
Mendeley readers
Attention Score in Context
| Title |
NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome
|
|---|---|
| Published in |
Clinica Chimica Acta, June 2012
|
| DOI | 10.1016/j.cca.2012.06.022 |
| Pubmed ID | |
| Authors |
Christopher W. Armstrong, Neil R. McGregor, John R. Sheedy, Ian Buttfield, Henry L. Butt, Paul R. Gooley |
| Abstract |
Chronic fatigue syndrome (CFS) is a debilitating multisystem disorder characterised by long-term fatigue with a variety of other symptoms including cognitive dysfunction, unrefreshing sleep, muscle pain, and post-exertional malaise. It is a poorly understood condition that occurs in ~5 in every 1000 individuals. We present here a preliminary study on the analysis of blood samples from 11 CFS and 10 control subjects through NMR metabolic profiling. Identified metabolites that were found to be significantly altered between the groups were subjected to correlation analysis to potentially elucidate disturbed metabolic pathways. Our results showed a significant reduction of glutamine (P=0.002) and ornithine (P<0.05) in the blood of the CFS samples. Correlation analysis of glutamine and ornithine with other metabolites in the CFS sera showed relationships with glucogenic amino acids and metabolites that participate in the urea cycle. This indicates a possible disturbance to amino acid and nitrogen metabolism. It would be beneficial to identify any potential biomarkers of CFS for accurate diagnosis of the disorder. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 32% |
| Canada | 2 | 8% |
| United Kingdom | 2 | 8% |
| Belgium | 1 | 4% |
| Unknown | 12 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 84% |
| Practitioners (doctors, other healthcare professionals) | 3 | 12% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Norway | 1 | 1% |
| Australia | 1 | 1% |
| Unknown | 67 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 12 | 17% |
| Student > Master | 12 | 17% |
| Student > Bachelor | 9 | 13% |
| Researcher | 8 | 11% |
| Student > Ph. D. Student | 5 | 7% |
| Other | 12 | 17% |
| Unknown | 12 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 24% |
| Biochemistry, Genetics and Molecular Biology | 11 | 16% |
| Agricultural and Biological Sciences | 11 | 16% |
| Chemistry | 4 | 6% |
| Nursing and Health Professions | 4 | 6% |
| Other | 12 | 17% |
| Unknown | 11 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2024.
All research outputs
#1,307,116
of 25,654,806 outputs
Outputs from Clinica Chimica Acta
#39
of 4,853 outputs
Outputs of similar age
#7,042
of 177,966 outputs
Outputs of similar age from Clinica Chimica Acta
#1
of 35 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,853 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.