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An evaluation of the immunogenicity and protective responses to Brachyspira hyodysenteriae recombinant SmpB vaccination

Overview of attention for article published in Veterinary Microbiology, November 2007
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2 patents

Citations

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25 Mendeley
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Title
An evaluation of the immunogenicity and protective responses to Brachyspira hyodysenteriae recombinant SmpB vaccination
Published in
Veterinary Microbiology, November 2007
DOI 10.1016/j.vetmic.2007.10.026
Pubmed ID
Authors

James Holden, Peter J. Coloe, Peter M. Smooker

Abstract

SmpB is an outer membrane protein of Brachyspira hyodysentariae that is present in some strains of the bacterium. It shares the same locus as SmpA, but all strains tested to date contain either one protein or the other, never both. In this study we have evaluated the efficacy of vaccination with SmpB to elicit immune responses in mice and to protect against a subsequent challenge. Immunised mice develop humoral and cellular responses to SmpB delivered as either a DNA vaccine or a recombinant protein, although the magnitude of the responses is greater after protein vaccination. The responses induced after protein vaccination offer moderate protection against disease and indicate that SmpB has potential as a component of a vaccine against B. hyodysentariae.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 4%
Canada 1 4%
Taiwan 1 4%
Unknown 22 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 20%
Researcher 4 16%
Student > Master 3 12%
Student > Bachelor 3 12%
Student > Postgraduate 2 8%
Other 5 20%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 36%
Veterinary Science and Veterinary Medicine 5 20%
Medicine and Dentistry 2 8%
Biochemistry, Genetics and Molecular Biology 2 8%
Unspecified 1 4%
Other 2 8%
Unknown 4 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 November 2020.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Veterinary Microbiology
#946
of 3,792 outputs
Outputs of similar age
#30,081
of 90,334 outputs
Outputs of similar age from Veterinary Microbiology
#10
of 28 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,792 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,334 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.