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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Global analysis of transcriptionally engaged yeast RNA polymerase III reveals extended tRNA transcripts
|
|---|---|
| Published in |
Genome Research, May 2016
|
| DOI | 10.1101/gr.205492.116 |
| Pubmed ID | |
| Authors |
Tomasz W. Turowski, Ewa Leśniewska, Clementine Delan-Forino, Camille Sayou, Magdalena Boguta, David Tollervey |
| Abstract |
RNA polymerase III (RNAPIII) synthesizes a range of highly abundant small stable RNAs, principally pre-tRNAs. Here we report the genome-wide analysis of nascent transcripts attached to RNAPIII under permissive and restrictive growth conditions. This revealed strikingly uneven polymerase distributions across transcription units, generally with a predominant 5' peak. This peak was higher for more heavily transcribed genes, suggesting that initiation site clearance is rate limiting during RNAPIII transcription. Down-regulation of RNAPIII transcription under stress conditions was found to be uneven; a subset of tRNA genes showed low response to nutrient shift or loss of the major transcription regulator Maf1, suggesting potential 'housekeeping' roles. Many tRNA genes were found to generate long, 3'-extended forms due to read-through of the canonical poly(U) terminators. The degree of read-through was anti-correlated with the density of U-residues in the nascent tRNA, and multiple, functional terminators can be located far downstream. The steady-state levels of 3'-extended pre-tRNA transcripts are low, apparently due to targeting by the nuclear surveillance machinery; especially the RNA-binding protein Nab2, cofactors for the nuclear exosome and the 5'-exonuclease Rat1. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 33% |
| United States | 1 | 17% |
| Poland | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 90 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 30% |
| Researcher | 13 | 14% |
| Student > Master | 10 | 11% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 8 | 9% |
| Other | 5 | 5% |
| Unknown | 19 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 36% |
| Agricultural and Biological Sciences | 33 | 36% |
| Medicine and Dentistry | 3 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 19 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2017.
All research outputs
#7,237,809
of 22,873,031 outputs
Outputs from Genome Research
#2,913
of 4,251 outputs
Outputs of similar age
#114,127
of 333,293 outputs
Outputs of similar age from Genome Research
#38
of 42 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 4,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.