Title |
Olea europaea leaf extract alters microRNA expression in human glioblastoma cells
|
---|---|
Published in |
Journal of Cancer Research and Clinical Oncology, June 2012
|
DOI | 10.1007/s00432-012-1261-8 |
Pubmed ID | |
Authors |
Berrin Tunca, Gulcin Tezcan, Gulsah Cecener, Unal Egeli, Secil Ak, Hulusi Malyer, Gulendam Tumen, Ayhan Bilir |
Abstract |
Glioblastoma multiforme (GBM) is the most common and the most lethal form of primary malignant tumors in the central nervous system. There is an increasing need for the development of more efficient therapeutic approaches for the treatment of these patients. One of the most attractive cancer therapy methods to date is the induction of tumor cell death by certain phytochemicals. Interestingly, bioactive compounds have been shown to alter micro RNA (miRNA) expression involved in several biological processes at the posttranscriptional level. The present study aimed to evaluate whether Olea europaea leaf extract (OLE) has an anticancer effect and modulates miRNA expression in GBM. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 2% |
United States | 1 | 2% |
Turkey | 1 | 2% |
Brazil | 1 | 2% |
Unknown | 62 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 20% |
Researcher | 11 | 17% |
Student > Bachelor | 7 | 11% |
Student > Postgraduate | 4 | 6% |
Student > Master | 4 | 6% |
Other | 14 | 21% |
Unknown | 13 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Agricultural and Biological Sciences | 14 | 21% |
Medicine and Dentistry | 8 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Nursing and Health Professions | 2 | 3% |
Other | 9 | 14% |
Unknown | 17 | 26% |