Title |
Breast and ovarian cancer risk management in a French cohort of 158 women carrying a BRCA1 or BRCA2 germline mutation: patient choices and outcome
|
---|---|
Published in |
Familial Cancer, June 2012
|
DOI | 10.1007/s10689-012-9539-1 |
Pubmed ID | |
Authors |
Pascale This, Anne de la Rochefordière, Alexia Savignoni, Marie Christine Falcou, Anne Tardivon, Fabienne Thibault, Séverine Alran, Virgine Fourchotte, Alfred Fitoussi, Benoit Couturaud, Sylvie Dolbeault, Remy J. Salmon, Brigitte Sigal-Zafrani, Bernard Asselain, Dominique Stoppa-Lyonnet |
Abstract |
Description of the various modalities of breast and ovarian cancer risk management, patient choices and their outcome in a single-center cohort of 158 unaffected women carrying a BRCA1 or BRCA2 germline mutation. Between 1998 and 2009, 158 unaffected women carrying a BRCA1 or BRCA2 gene mutation were prospectively followed. The following variables were studied: general and gynecological characteristics, data concerning any prophylactic procedures, and data concerning the outcome of these patients. Median age at inclusion was 37 years and median follow-up was 54 months. Among the 156 women who received systematic information about prophylactic mastectomy, 5.3 % decided to undergo surgery within 36 months after disclosure of genetic results. Prophylactic salpingo-oophorectomy was performed in 68 women. Among women in whom follow-up started between the ages of 40 and 50 years, prophylactic salpingo-oophorectomy was performed, within 24 months after start of follow-up, in 83.7 and 52 % of women with BRCA1 and BRCA2 mutations, respectively. Twenty four women developed breast cancer. Ovarian cancer was detected during prophylactic salpingo-oophorectomy in two women (2.9 %). In this cohort of French women carrying BRCA1/2 mutations, prophylactic mastectomy was a rarely used option. However, good compliance with prophylactic salpingo-oophorectomy was observed. This study confirms the high breast cancer risk in these women. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 17% |
Professor > Associate Professor | 4 | 11% |
Student > Master | 4 | 11% |
Researcher | 3 | 9% |
Student > Postgraduate | 2 | 6% |
Other | 7 | 20% |
Unknown | 9 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 34% |
Nursing and Health Professions | 4 | 11% |
Agricultural and Biological Sciences | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Business, Management and Accounting | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 26% |