| Title |
Studies on the mode of action of bretylium and guanethidine in post-ganglionic sympathetic nerve fibres
|
|---|---|
| Published in |
Naunyn-Schmiedeberg's Archives of Pharmacology, November 1988
|
| DOI | 10.1007/bf00179321 |
| Pubmed ID | |
| Authors |
James A. Brock, Thomas C. Cunnane |
| Abstract |
1. The effects of bretylium and guanethidine on the nerve terminal impulse and transmitter release from sympathetic postganglionic nerve terminals in the guinea-pig vas deferens have been studied in vitro using focal extracellular recording. Excitatory junction currents (EJCs) were used as a measure of transmitter release. 2. Both bretylium and guanethidine altered the configuration of the nerve terminal impulse in a manner consistent with their being local anaesthetics. 3. Bretylium (1-3 microM) only completely inhibited transmitter release when impulse propagation in the sympathetic nerve terminal was blocked. 4. In contrast, guanethidine (1-10 microM) could block transmitter release with little effect on the configuration of the nerve terminal impulse. 5. The inhibitory effects of these agents on both the nerve terminal impulse and on transmitter release were reversed by the indirectly acting sympathomimetic agent, d-amphetamine (1-10 microM). 6. Using this technique the mechanisms of action of drugs known to modify the transmitter release in sympathetic nerve terminals can be more precisely determined. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor > Associate Professor | 2 | 40% |
| Professor | 1 | 20% |
| Student > Ph. D. Student | 1 | 20% |
| Student > Master | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 December 2019.
All research outputs
#7,482,726
of 22,873,031 outputs
Outputs from Naunyn-Schmiedeberg's Archives of Pharmacology
#348
of 1,731 outputs
Outputs of similar age
#3,891
of 14,105 outputs
Outputs of similar age from Naunyn-Schmiedeberg's Archives of Pharmacology
#3
of 3 outputs
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