Title |
MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells
|
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Published in |
Gene, March 2002
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DOI | 10.1016/s0378-1119(02)00434-1 |
Pubmed ID | |
Authors |
Claudia C. Gregorio-King, Janet L. McLeod, Fiona McL. Collier, Gregory R. Collier, Karyn A. Bolton, Gavin J. Van Der Meer, Jim Apostolopoulos, Mark A. Kirkland |
Abstract |
We have utilized differential display polymerase chain reaction to investigate the gene expression of hematopoietic progenitor cells from adult bone marrow and umbilical cord blood. A differentially expressed gene was identified in CD34+ hematopoietic progenitor cells, with low expression in CD34- cells. We have obtained the full coding sequence of this gene which we designated human mammalian ependymin-related protein 1 (MERP1). Expression of MERP1 was found in a variety of normal human tissues, and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34+ cells, respectively, compared to CD34- cells. Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation. Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and protocadherins. |
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Demographic breakdown
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