| Title |
Lymphocytes in obesity-related adipose tissue inflammation
|
|---|---|
| Published in |
Diabetologia, June 2012
|
| DOI | 10.1007/s00125-012-2607-0 |
| Pubmed ID | |
| Authors |
A. Chatzigeorgiou, K. P. Karalis, S. R. Bornstein, T. Chavakis |
| Abstract |
Inflammation in the white adipose tissue (WAT) is considered a major player in the development of insulin resistance. The role of macrophages accumulating in the WAT during obesity, promoting WAT inflammation and insulin resistance is well established. In contrast, less is known about the role of lymphocytes. Recent studies have implicated different lymphocyte subsets in WAT inflammation. For instance, cytotoxic CD8(+) T cells infiltrating the WAT may contribute to the recruitment, differentiation and activation of macrophages. On the other hand, a differential role for CD4(+) Th1 and CD4(+) Th2 cells has been suggested. Levels of WAT regulatory T cells decrease during the course of obesity and may represent a crucial factor for the maintenance of insulin sensitivity. Moreover, activation of natural killer T cells, an innate-like T cell population, which recognises lipid antigens, promotes insulin resistance and WAT inflammation. Finally, B cells may infiltrate WAT very early in response to high-fat feeding and worsen glucose metabolism through modulation of T cells and the production of pathogenic antibodies. These interesting new findings however bear controversies and introduce novel, yet unanswered, questions. Here, we review and discuss the impact of the different lymphocyte subsets in obesity-related WAT inflammation and attempt to identify the open questions to be answered by future studies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 115 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 25% |
| Researcher | 19 | 16% |
| Student > Master | 17 | 14% |
| Student > Doctoral Student | 12 | 10% |
| Student > Bachelor | 10 | 8% |
| Other | 16 | 14% |
| Unknown | 15 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 29% |
| Medicine and Dentistry | 23 | 19% |
| Biochemistry, Genetics and Molecular Biology | 18 | 15% |
| Immunology and Microbiology | 6 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Other | 11 | 9% |
| Unknown | 22 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2012.
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#18,309,495
of 22,669,724 outputs
Outputs from Diabetologia
#4,665
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#126,396
of 164,432 outputs
Outputs of similar age from Diabetologia
#36
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