| Title |
A Recombinant DNA Plasmid Encoding the sIL-4R-NAP Fusion Protein Suppress Airway Inflammation in an OVA-Induced Mouse Model of Asthma
|
|---|---|
| Published in |
Inflammation, May 2016
|
| DOI | 10.1007/s10753-016-0375-6 |
| Pubmed ID | |
| Authors |
Xin Liu, Guo Fu, Zhenyu Ji, Xiabing Huang, Cong Ding, Hui Jiang, Xiaolong Wang, Mingxuan Du, Ting Wang, Qiaozhen Kang |
| Abstract |
Asthma is a chronic inflammatory airway disease. It was prevalently perceived that Th2 cells played the crucial role in asthma pathogenesis, which has been identified as the important target for anti-asthma therapy. The soluble IL-4 receptor (sIL-4R), which is the decoy receptor for Th2 cytokine IL-4, has been reported to be effective in treating asthma in phase I/II clinical trail. To develop more efficacious anti-asthma agent, we attempt to test whether the Helicobacter pylori neutrophil-activating protein (HP-NAP), a novel TLR2 agonist, would enhance the efficacy of sIL-4R in anti-asthma therapy. In our work, we constructed a pcDNA3.1-sIL-4R-NAP plasmid, named PSN, encoding fusion protein of murine sIL-4R and HP-NAP. PSN significantly inhibited airway inflammation, decreased the serum OVA-specific IgE levels and remodeled the Th1/Th2 balance. Notably, PSN is more effective on anti-asthma therapy comparing with plasmid only expressing sIL-4R. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 2 | 25% |
| Student > Bachelor | 2 | 25% |
| Student > Doctoral Student | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Professor | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 3 | 38% |
| Biochemistry, Genetics and Molecular Biology | 2 | 25% |
| Environmental Science | 1 | 13% |
| Medicine and Dentistry | 1 | 13% |
| Unknown | 1 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2017.
All research outputs
#18,459,684
of 22,873,031 outputs
Outputs from Inflammation
#609
of 1,052 outputs
Outputs of similar age
#249,952
of 333,164 outputs
Outputs of similar age from Inflammation
#9
of 22 outputs
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