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Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women

Overview of attention for article published in Diabetes, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
24 X users
facebook
2 Facebook pages
reddit
1 Redditor

Citations

dimensions_citation
218 Dimensions

Readers on

mendeley
299 Mendeley
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Title
Connections Between the Gut Microbiome and Metabolic Hormones in Early Pregnancy in Overweight and Obese Women
Published in
Diabetes, May 2016
DOI 10.2337/db16-0278
Pubmed ID
Authors

Luisa F. Gomez-Arango, Helen L. Barrett, H. David McIntyre, Leonie K. Callaway, Mark Morrison, Marloes Dekker Nitert

Abstract

Overweight and obese women are at a higher risk of developing gestational diabetes mellitus. The gut microbiome could modulate metabolic health and may affect insulin resistance and lipid metabolism. The aim of this study was to reveal any relationships between gut microbiome composition and circulating metabolic hormones in overweight and obese pregnant women at 16 weeks gestation. Fecal microbiota profiles from overweight (n=29) and obese (n=41) pregnant women were assessed by 16S rRNA sequencing. Fasting metabolic hormone (insulin, c-peptide, glucagon, incretins and adipokines) concentrations were measured using multiplex ELISA. Metabolic hormone levels as well as microbiome profiles differed between overweight and obese women. Furthermore, changes in some metabolic hormone levels were correlated with alterations in the relative abundance of specific microbes. Adipokine levels were strongly correlated with Ruminococcaceae and Lachnospiraceae, which are dominant families in energy metabolism. Insulin was positively correlated with the genus Collinsella. GIP was positively correlated with the genus Coprococcus but negatively with family Ruminococcaceae This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in overweight and obese pregnant women at 16 weeks gestation. These results suggest that manipulation of the gut microbiome composition may have the potential to influence pregnancy metabolism.

X Demographics

X Demographics

The data shown below were collected from the profiles of 24 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 299 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 298 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 14%
Student > Master 41 14%
Student > Bachelor 38 13%
Researcher 33 11%
Other 16 5%
Other 52 17%
Unknown 78 26%
Readers by discipline Count As %
Medicine and Dentistry 71 24%
Agricultural and Biological Sciences 31 10%
Biochemistry, Genetics and Molecular Biology 29 10%
Immunology and Microbiology 22 7%
Nursing and Health Professions 21 7%
Other 31 10%
Unknown 94 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2017.
All research outputs
#1,203,516
of 23,576,969 outputs
Outputs from Diabetes
#475
of 9,347 outputs
Outputs of similar age
#23,061
of 334,981 outputs
Outputs of similar age from Diabetes
#18
of 126 outputs
Altmetric has tracked 23,576,969 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,347 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,981 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 126 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.