| Title |
The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
|
|---|---|
| Published in |
Human Genetics, June 2012
|
| DOI | 10.1007/s00439-012-1193-z |
| Pubmed ID | |
| Authors |
Claire Bacon, Gudrun A. Rappold |
| Abstract |
Rare disruptions of FOXP2 have been strongly implicated in deficits in language development. Research over the past decade has suggested a role in the formation of underlying neural circuits required for speech. Until recently no evidence existed to suggest that the closely related FOXP1 gene played a role in neurodevelopmental processes. However, in the last few years, novel rare disruptions in FOXP1 have been reported in multiple cases of cognitive dysfunction, including intellectual disability and autism spectrum disorder, together with language impairment. As FOXP1 and FOXP2 form heterodimers for transcriptional regulation, one may assume that they co-operate in common neurodevelopmental pathways through the co-regulation of common targets. Here we compare the phenotypic consequences of FOXP1 and FOXP2 impairment, drawing on well-known studies from the past as well as recent exciting findings and consider what these tell us regarding the functions of these two genes in neural development. |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 3 | 2% |
| United States | 2 | 1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 130 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 27 | 20% |
| Researcher | 26 | 19% |
| Student > Ph. D. Student | 20 | 14% |
| Student > Bachelor | 17 | 12% |
| Professor | 7 | 5% |
| Other | 18 | 13% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 40 | 29% |
| Biochemistry, Genetics and Molecular Biology | 17 | 12% |
| Medicine and Dentistry | 17 | 12% |
| Neuroscience | 12 | 9% |
| Psychology | 7 | 5% |
| Other | 17 | 12% |
| Unknown | 28 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 January 2023.
All research outputs
#4,388,312
of 25,759,158 outputs
Outputs from Human Genetics
#409
of 2,978 outputs
Outputs of similar age
#28,435
of 178,175 outputs
Outputs of similar age from Human Genetics
#3
of 23 outputs
Altmetric has tracked 25,759,158 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,978 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,175 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.