Title |
Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database
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Published in |
BMC Neurology, June 2012
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DOI | 10.1186/1471-2377-12-47 |
Pubmed ID | |
Authors |
Ravi Kiran Reddy Kalathur, Miguel A Hernández-Prieto, Matthias E Futschik |
Abstract |
Huntington's disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms involved in HD in a holistic manner. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 13% |
Sweden | 1 | 13% |
Egypt | 1 | 13% |
Spain | 1 | 13% |
Unknown | 4 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 63% |
Practitioners (doctors, other healthcare professionals) | 3 | 38% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 4% |
United Kingdom | 1 | 1% |
Australia | 1 | 1% |
Unknown | 66 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 25% |
Student > Bachelor | 14 | 20% |
Student > Ph. D. Student | 9 | 13% |
Student > Master | 8 | 11% |
Other | 6 | 8% |
Other | 9 | 13% |
Unknown | 7 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 30% |
Medicine and Dentistry | 15 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Neuroscience | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 6% |
Other | 9 | 13% |
Unknown | 10 | 14% |