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The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat

Overview of attention for article published in PLoS Pathogens, June 2012
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Title
The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat
Published in
PLoS Pathogens, June 2012
DOI 10.1371/journal.ppat.1002753
Pubmed ID
Authors

Nada Abdelmagid, Biborka Bereczky-Veress, André Ortlieb Guerreiro-Cacais, Petra Bergman, Katarina M. Luhr, Tomas Bergström, Birgit Sköldenberg, Fredrik Piehl, Tomas Olsson, Margarita Diez

Abstract

Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 25%
Student > Bachelor 3 19%
Researcher 3 19%
Student > Master 2 13%
Professor 1 6%
Other 2 13%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 5 31%
Biochemistry, Genetics and Molecular Biology 4 25%
Agricultural and Biological Sciences 4 25%
Nursing and Health Professions 1 6%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2012.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from PLoS Pathogens
#8,707
of 9,467 outputs
Outputs of similar age
#138,789
of 177,597 outputs
Outputs of similar age from PLoS Pathogens
#123
of 139 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 9,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
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We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.