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Landscape of Somatic Retrotransposition in Human Cancers

Overview of attention for article published in Science, June 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

blogs
3 blogs
twitter
45 X users
patent
11 patents
facebook
5 Facebook pages
googleplus
3 Google+ users
f1000
1 research highlight platform

Citations

dimensions_citation
624 Dimensions

Readers on

mendeley
700 Mendeley
citeulike
16 CiteULike
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Title
Landscape of Somatic Retrotransposition in Human Cancers
Published in
Science, June 2012
DOI 10.1126/science.1222077
Pubmed ID
Authors

Eunjung Lee, Rebecca Iskow, Lixing Yang, Omer Gokcumen, Psalm Haseley, Lovelace J. Luquette, Jens G. Lohr, Christopher C. Harris, Li Ding, Richard K. Wilson, David A. Wheeler, Richard A. Gibbs, Raju Kucherlapati, Charles Lee, Peter V. Kharchenko, Peter J. Park, The Cancer Genome Atlas Research Network

Abstract

Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress TE activity may facilitate mutagenic retrotranspositions. We performed single-nucleotide resolution analysis of TE insertions in 43 high-coverage whole-genome sequencing data sets from five cancer types. We identified 194 high-confidence somatic TE insertions, as well as thousands of polymorphic TE insertions in matched normal genomes. Somatic insertions were present in epithelial tumors but not in blood or brain cancers. Somatic L1 insertions tend to occur in genes that are commonly mutated in cancer, disrupt the expression of the target genes, and are biased toward regions of cancer-specific DNA hypomethylation, highlighting their potential impact in tumorigenesis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 700 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 20 3%
United Kingdom 4 <1%
Brazil 4 <1%
Russia 3 <1%
Denmark 3 <1%
Canada 3 <1%
France 2 <1%
Belgium 2 <1%
Netherlands 2 <1%
Other 7 1%
Unknown 650 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 170 24%
Researcher 170 24%
Student > Master 55 8%
Student > Bachelor 48 7%
Professor > Associate Professor 38 5%
Other 113 16%
Unknown 106 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 294 42%
Biochemistry, Genetics and Molecular Biology 175 25%
Medicine and Dentistry 54 8%
Computer Science 16 2%
Immunology and Microbiology 9 1%
Other 35 5%
Unknown 117 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 59. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2023.
All research outputs
#720,644
of 25,397,764 outputs
Outputs from Science
#15,381
of 82,955 outputs
Outputs of similar age
#3,586
of 177,620 outputs
Outputs of similar age from Science
#99
of 845 outputs
Altmetric has tracked 25,397,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,955 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 845 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.