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Attention Score in Context
| Title |
Preparation of optimized lipid-coated calcium phosphate nanoparticles for enhanced in vitro gene delivery to breast cancer cells
|
|---|---|
| Published in |
Journal of Materials Chemistry B: Materials for biology and medicine, January 2015
|
| DOI | 10.1039/c5tb00912j |
| Pubmed ID | |
| Authors |
Jie Tang, Li Li, Christopher B. Howard, Stephen M. Mahler, Leaf Huang, Zhi Ping Xu |
| Abstract |
Lipid coated calcium phosphate (LCP) nanoparticles (NPs) remain an attractive option for siRNA systemic delivery. Previous research has shown that the stoichiometry of reactants affects the size and morphology of nanostructured calcium phosphate (CaP) particles. However, it is unclear how synthesis parameters such as the Ca/P molar ratio and mixing style influence the siRNA loading and protection by LCP NPs, and subsequent siRNA delivery efficiency. In this research, we found that the Ca/P molar ratio is critical in controlling the size, zeta potential, dispersion state, siRNA loading and protection. Based on the siRNA loading efficiency and capacity as well as siRNA protection effectiveness, we suggested an optimized LCP NPs delivery system. The optimized LCP NPs had a hollow, spherical structure with the average particle size of ~40 nm and were able to maintain their stability in serum containing media and PBS for over 24 h, with a pH-sensitive dissolution property. The superior ability of optimized LCP NPs to maintain the integrity of encapsulated siRNA and the colloidal stability in culture medium allow this formulation to achieve improved cellular accumulation of siRNA and enhanced growth inhibition of human breast cancer cells in vitro, compared with the commercial transfection agent Oligofectamine(™). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 26% |
| Student > Master | 12 | 17% |
| Researcher | 8 | 12% |
| Student > Doctoral Student | 5 | 7% |
| Student > Bachelor | 4 | 6% |
| Other | 9 | 13% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 15 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 12% |
| Engineering | 7 | 10% |
| Agricultural and Biological Sciences | 6 | 9% |
| Materials Science | 6 | 9% |
| Other | 9 | 13% |
| Unknown | 18 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#23,109,385
of 25,756,911 outputs
Outputs from Journal of Materials Chemistry B: Materials for biology and medicine
#3,422
of 5,583 outputs
Outputs of similar age
#308,877
of 361,654 outputs
Outputs of similar age from Journal of Materials Chemistry B: Materials for biology and medicine
#237
of 255 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,583 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.