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A Functional –1 Ribosomal Frameshift Signal in the Human Paraneoplastic Ma3 Gene*

Overview of attention for article published in Journal of Biological Chemistry, January 2006
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Title
A Functional –1 Ribosomal Frameshift Signal in the Human Paraneoplastic Ma3 Gene*
Published in
Journal of Biological Chemistry, January 2006
DOI 10.1074/jbc.m511629200
Pubmed ID
Authors

Norma M. Wills, Barry Moore, Andrew Hammer, Raymond F. Gesteland, John F. Atkins

Abstract

A bioinformatics approach to finding new cases of -1 frameshifting in the expression of human genes revealed a classical retrovirus-like heptanucleotide shift site followed by a potential structural stimulator in the paraneoplastic antigen Ma3 and Ma5 genes. Analysis of the sequence 3' of the shift site demonstrated that an RNA pseudoknot in Ma3 is important for promoting efficient -1 frame-shifting. Ma3 is a member of a family of six genes in humans whose protein products contain homology to retroviral Gag proteins. The -1 frameshift site and pseudoknot structure are conserved in other mammals, but there are some sequence differences. Although the functions of the Ma genes are unknown, the serious neurological effects of ectopic expression in tumor cells indicate their importance in the brain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 68 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 22%
Student > Ph. D. Student 14 21%
Student > Master 13 19%
Student > Bachelor 5 7%
Professor 5 7%
Other 9 13%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 44%
Biochemistry, Genetics and Molecular Biology 23 34%
Medicine and Dentistry 3 4%
Physics and Astronomy 2 3%
Immunology and Microbiology 1 1%
Other 3 4%
Unknown 6 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2022.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Journal of Biological Chemistry
#76,082
of 85,238 outputs
Outputs of similar age
#150,051
of 172,933 outputs
Outputs of similar age from Journal of Biological Chemistry
#451
of 497 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 85,238 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,933 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 497 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.