| Title |
Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships
|
|---|---|
| Published in |
Human Genetics, June 2012
|
| DOI | 10.1007/s00439-012-1189-8 |
| Pubmed ID | |
| Authors |
Victoria K. Cortessis, Duncan C. Thomas, A. Joan Levine, Carrie V. Breton, Thomas M. Mack, Kimberly D. Siegmund, Robert W. Haile, Peter W. Laird |
| Abstract |
Changes in epigenetic marks such as DNA methylation and histone acetylation are associated with a broad range of disease traits, including cancer, asthma, metabolic disorders, and various reproductive conditions. It seems plausible that changes in epigenetic state may be induced by environmental exposures such as malnutrition, tobacco smoke, air pollutants, metals, organic chemicals, other sources of oxidative stress, and the microbiome, particularly if the exposure occurs during key periods of development. Thus, epigenetic changes could represent an important pathway by which environmental factors influence disease risks, both within individuals and across generations. We discuss some of the challenges in studying epigenetic mediation of pathogenesis and describe some unique opportunities for exploring these phenomena. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 57% |
| United Kingdom | 1 | 14% |
| France | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 1 | 14% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 483 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 9 | 2% |
| United Kingdom | 6 | 1% |
| Spain | 4 | <1% |
| Germany | 2 | <1% |
| Hong Kong | 2 | <1% |
| India | 2 | <1% |
| Netherlands | 1 | <1% |
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 12 | 2% |
| Unknown | 443 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 103 | 21% |
| Researcher | 90 | 19% |
| Student > Master | 69 | 14% |
| Student > Bachelor | 53 | 11% |
| Professor > Associate Professor | 20 | 4% |
| Other | 83 | 17% |
| Unknown | 65 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 177 | 37% |
| Medicine and Dentistry | 66 | 14% |
| Biochemistry, Genetics and Molecular Biology | 61 | 13% |
| Psychology | 14 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 2% |
| Other | 69 | 14% |
| Unknown | 85 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2017.
All research outputs
#1,861,718
of 22,669,724 outputs
Outputs from Human Genetics
#153
of 2,948 outputs
Outputs of similar age
#12,094
of 164,434 outputs
Outputs of similar age from Human Genetics
#1
of 23 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,948 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,434 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.