Title |
The Ecology of Antibiotic Use in the ICU: Homogeneous Prescribing of Cefepime but Not Tazocin Selects for Antibiotic Resistant Infection
|
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Published in |
PLOS ONE, June 2012
|
DOI | 10.1371/journal.pone.0038719 |
Pubmed ID | |
Authors |
Andrew N. Ginn, Agnieszka M. Wiklendt, Heather F. Gidding, Narelle George, James S. O’Driscoll, Sally R. Partridge, Brian I. O’Toole, Rita A. Perri, Joan Faoagali, John E. Gallagher, Jeffrey Lipman, Jonathan R. Iredell |
Abstract |
Antibiotic homogeneity is thought to drive resistance but in vivo data are lacking. In this study, we determined the impact of antibiotic homogeneity per se, and of cefepime versus antipseudomonal penicillin/β-lactamase inhibitor combinations (APP-β), on the likelihood of infection or colonisation with antibiotic resistant bacteria and/or two commonly resistant nosocomial pathogens (methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa). A secondary question was whether antibiotic cycling was associated with adverse outcomes including mortality, length of stay, and antibiotic resistance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Mexico | 1 | 1% |
Unknown | 69 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 13% |
Student > Master | 8 | 11% |
Student > Ph. D. Student | 8 | 11% |
Student > Bachelor | 6 | 8% |
Lecturer | 5 | 7% |
Other | 14 | 20% |
Unknown | 21 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 30% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 10% |
Agricultural and Biological Sciences | 5 | 7% |
Nursing and Health Professions | 3 | 4% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Other | 9 | 13% |
Unknown | 23 | 32% |