| Title |
Neocentromeres and epigenetically inherited features of centromeres
|
|---|---|
| Published in |
Chromosome Research, June 2012
|
| DOI | 10.1007/s10577-012-9296-x |
| Pubmed ID | |
| Authors |
Laura S. Burrack, Judith Berman |
| Abstract |
Neocentromeres are ectopic sites where new functional kinetochores assemble and permit chromosome segregation. Neocentromeres usually form following genomic alterations that remove or disrupt centromere function. The ability to form neocentromeres is conserved in eukaryotes ranging from fungi to mammals. Neocentromeres that rescue chromosome fragments in cells with gross chromosomal rearrangements are found in several types of human cancers, and in patients with developmental disabilities. In this review, we discuss the importance of neocentromeres to human health and evaluate recently developed model systems to study neocentromere formation, maintenance, and function in chromosome segregation. Additionally, studies of neocentromeres provide insight into native centromeres; analysis of neocentromeres found in human clinical samples and induced in model organisms distinguishes features of centromeres that are dependent on centromere DNA from features that are epigenetically inherited together with the formation of a functional kinetochore. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Russia | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 91 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 21 | 22% |
| Researcher | 19 | 20% |
| Student > Ph. D. Student | 15 | 16% |
| Student > Master | 7 | 7% |
| Professor > Associate Professor | 6 | 6% |
| Other | 15 | 16% |
| Unknown | 11 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 46 | 49% |
| Biochemistry, Genetics and Molecular Biology | 26 | 28% |
| Medicine and Dentistry | 6 | 6% |
| Computer Science | 2 | 2% |
| Immunology and Microbiology | 1 | 1% |
| Other | 0 | 0% |
| Unknown | 13 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 June 2022.
All research outputs
#6,109,584
of 22,669,724 outputs
Outputs from Chromosome Research
#102
of 507 outputs
Outputs of similar age
#42,741
of 164,330 outputs
Outputs of similar age from Chromosome Research
#2
of 11 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 507 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has done well, scoring higher than 78% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.