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Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish

Overview of attention for article published in Translational Psychiatry, May 2016
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  • Average Attention Score compared to outputs of the same age and source

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Title
Developmental suppression of schizophrenia-associated miR-137 alters sensorimotor function in zebrafish
Published in
Translational Psychiatry, May 2016
DOI 10.1038/tp.2016.88
Pubmed ID
Authors

J Giacomotto, A P Carroll, S Rinkwitz, B Mowry, M J Cairns, T S Becker

Abstract

The neurodevelopmentally regulated microRNA miR-137 was strongly implicated as risk locus for schizophrenia in the most recent genome wide association study coordinated by the Psychiatric Genome Consortium (PGC). This molecule is highly conserved in vertebrates enabling the investigation of its function in the developing zebrafish. We utilized this model system to achieve overexpression and suppression of miR-137, both transiently and stably through transgenesis. While miR-137 overexpression was not associated with an observable specific phenotype, downregulation by antisense morpholino and/or transgenic expression of miR-sponge RNA induced significant impairment of both embryonic and larval touch-sensitivity without compromising overall anatomical development. We observed miR-137 expression and activity in sensory neurons including Rohon-Beard neurons and dorsal root ganglia, two neuronal cell types that confer touch-sensitivity in normal zebrafish, suggesting a role of these cell types in the observed phenotype. The lack of obvious anatomical or histological pathology in these cells, however, suggested that subtle axonal network defects or a change in synaptic function and neural connectivity might be responsible for the behavioral phenotype rather than a change in the cellular morphology or neuroanatomy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 13%
Researcher 5 13%
Student > Bachelor 4 11%
Student > Doctoral Student 3 8%
Student > Postgraduate 3 8%
Other 5 13%
Unknown 13 34%
Readers by discipline Count As %
Medicine and Dentistry 5 13%
Agricultural and Biological Sciences 4 11%
Neuroscience 4 11%
Biochemistry, Genetics and Molecular Biology 2 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 5 13%
Unknown 17 45%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2017.
All research outputs
#6,304,781
of 22,873,031 outputs
Outputs from Translational Psychiatry
#1,681
of 3,232 outputs
Outputs of similar age
#99,799
of 334,086 outputs
Outputs of similar age from Translational Psychiatry
#37
of 70 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,232 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,086 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.