| Title |
The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice
|
|---|---|
| Published in |
Metabolic Brain Disease, May 2016
|
| DOI | 10.1007/s11011-016-9839-5 |
| Pubmed ID | |
| Authors |
Xuefeng Yu, Xi Jiang, Xiangming Zhang, Ziwei Chen, Lexing Xu, Lei Chen, Guokang Wang, Jianchun Pan |
| Abstract |
Major depressive disorder (MDD) involves a series of pathological changes including the inflammation and increased cytokine levels. Fisetin, a natural flavonoid, has anti-inflammatory and antioxidant, and also has been shown in our previous studies to exert anti-depressant-like properties. The present study aimed to investigate the effect of fisetin on lipopolysaccharide (LPS)-induced depressive-like behavior and inflammation in mice. The results suggested that the immobility time in the forced swimming test (FST) and tail suspension test (TST) were increased at 6 h, 12 h and 24 h after LPS injection (0.83 mg/kg). However, only the group of 24 h treatment did not show any effect on locomotion counts. Pretreatment with fisetin at doses of 20, 40 and 80 mg/kg (p.o.) for 7 days reversed LPS-induced alterations of the immobility time in both of these two tests. Further neurochemical assays suggested that pretreatment with fisetin reversed LPS-induced overexpression of pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) in the hippocampus and the prefrontal cortex (PFC). Moreover, higher dose of fisetin effectively antagonized iNOS mRNA expression and nitrite levels via the modulation of NF-κB in the hippocampus and PFC. Taken together, fisetin may be an effective therapeutic agent for LPS-induced depressive-like behaviors, which is due to its anti-inflammatory property. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 50 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 20% |
| Student > Bachelor | 7 | 14% |
| Student > Ph. D. Student | 6 | 12% |
| Researcher | 3 | 6% |
| Student > Postgraduate | 3 | 6% |
| Other | 4 | 8% |
| Unknown | 17 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 18% |
| Neuroscience | 6 | 12% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Agricultural and Biological Sciences | 3 | 6% |
| Psychology | 2 | 4% |
| Other | 8 | 16% |
| Unknown | 18 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#18,459,684
of 22,873,031 outputs
Outputs from Metabolic Brain Disease
#707
of 1,054 outputs
Outputs of similar age
#249,956
of 333,164 outputs
Outputs of similar age from Metabolic Brain Disease
#14
of 21 outputs
Altmetric has tracked 22,873,031 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,054 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
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We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.