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Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

Overview of attention for article published in Nature Cell Biology, July 2012
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Title
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
Published in
Nature Cell Biology, July 2012
DOI 10.1038/ncb2532
Pubmed ID
Authors

Aparna Ratheesh, Guillermo A. Gomez, Rashmi Priya, Suzie Verma, Eva M. Kovacs, Kai Jiang, Nicholas H. Brown, Anna Akhmanova, Samantha J. Stehbens, Alpha S. Yap

Abstract

The biological impact of Rho depends critically on the precise subcellular localization of its active, GTP-loaded form. This can potentially be determined by the balance between molecules that promote nucleotide exchange or GTP hydrolysis. However, how these activities may be coordinated is poorly understood. We now report a molecular pathway that achieves exactly this coordination at the epithelial zonula adherens. We identify an extramitotic activity of the centralspindlin complex, better understood as a cytokinetic regulator, which localizes to the interphase zonula adherens by interacting with the cadherin-associated protein, α-catenin. Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA. Centralspindlin also inhibits the junctional localization of p190 B RhoGAP, which can inactivate Rho. Thus, a conserved molecular ensemble that governs Rho activation during cytokinesis is used in interphase cells to control the Rho GTPase cycle at the zonula adherens.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 221 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Netherlands 2 <1%
United Kingdom 2 <1%
France 1 <1%
Canada 1 <1%
Spain 1 <1%
Unknown 212 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 65 29%
Student > Ph. D. Student 63 29%
Student > Master 18 8%
Student > Bachelor 15 7%
Professor > Associate Professor 14 6%
Other 23 10%
Unknown 23 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 108 49%
Biochemistry, Genetics and Molecular Biology 66 30%
Engineering 5 2%
Neuroscience 5 2%
Physics and Astronomy 5 2%
Other 7 3%
Unknown 25 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2012.
All research outputs
#12,565,774
of 22,669,724 outputs
Outputs from Nature Cell Biology
#2,931
of 3,812 outputs
Outputs of similar age
#85,890
of 163,718 outputs
Outputs of similar age from Nature Cell Biology
#29
of 55 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,812 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 21.0. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,718 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.