| Title |
Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina
|
|---|---|
| Published in |
Biotechnology for Biofuels and Bioproducts, September 2009
|
| DOI | 10.1186/1754-6834-2-19 |
| Pubmed ID | |
| Authors |
Christian P Kubicek, Marianna Mikus, André Schuster, Monika Schmoll, Bernhard Seiboth |
| Abstract |
Hypocrea jecorina (= Trichoderma reesei) is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering. |
Mendeley readers
The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 3 | <1% |
| India | 2 | <1% |
| France | 2 | <1% |
| United Kingdom | 2 | <1% |
| Austria | 2 | <1% |
| Indonesia | 1 | <1% |
| Malaysia | 1 | <1% |
| Germany | 1 | <1% |
| United Arab Emirates | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 296 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 19% |
| Researcher | 53 | 17% |
| Student > Master | 44 | 14% |
| Student > Bachelor | 36 | 12% |
| Student > Doctoral Student | 21 | 7% |
| Other | 51 | 16% |
| Unknown | 47 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 141 | 45% |
| Biochemistry, Genetics and Molecular Biology | 67 | 21% |
| Engineering | 15 | 5% |
| Chemical Engineering | 6 | 2% |
| Environmental Science | 6 | 2% |
| Other | 20 | 6% |
| Unknown | 57 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2023.
All research outputs
#2,062,358
of 25,374,917 outputs
Outputs from Biotechnology for Biofuels and Bioproducts
#79
of 1,578 outputs
Outputs of similar age
#6,361
of 102,315 outputs
Outputs of similar age from Biotechnology for Biofuels and Bioproducts
#2
of 7 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,578 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,315 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.