| Title |
Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents
|
|---|---|
| Published in |
ADHD Attention Deficit and Hyperactivity Disorders, July 2012
|
| DOI | 10.1007/s12402-012-0084-4 |
| Pubmed ID | |
| Authors |
Mats Johnson, Jan-Eric Månsson, Sven Östlund, Gunnar Fransson, Björn Areskoug, Kerstin Hjalmarsson, Magnus Landgren, Björn Kadesjö, Christopher Gillberg |
| Abstract |
The aim of this study was to assess baseline levels and changes in plasma fatty acid profiles in children and adolescents with ADHD, in a placebo-controlled study with Omega 3/6 supplementation, and to compare with treatment response. Seventy-five children and adolescents aged 8-18 years with DSM-IV ADHD were randomized to 3 months of Omega 3/6 (Equazen eye q) or placebo, followed by 3 months of open phase Omega 3/6 for all. n-3, n-6, n-6/n-3 ratio, EPA and DHA in plasma were measured at baseline, 3 and 6 months. Subjects with more than 25 % reduction in ADHD symptoms were classified as responders. At baseline, no significant differences in mean fatty acid levels were seen across active/placebo groups or responder/non-responder groups. The 0-3 month changes in all parameters were significantly greater in the active group (p < 0.01). Compared to non-responders, the 6-month responders had significantly greater n-3 increase at 3 months and decrease in n-6/n-3 ratio at 3 and 6 months (p < 0.05). Omega 3/6 supplementation had a clear impact on fatty acid composition of plasma phosphatidyl choline in active versus placebo group, and the fatty acid changes appear to be associated with treatment response. The most pronounced and long-lasting changes for treatment responders compared to non-responders were in the n-6/n-3 ratio. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 25% |
| Netherlands | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 1% |
| United Kingdom | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 93 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 15 | 16% |
| Student > Master | 13 | 14% |
| Researcher | 11 | 11% |
| Student > Postgraduate | 10 | 10% |
| Student > Ph. D. Student | 10 | 10% |
| Other | 16 | 17% |
| Unknown | 21 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 30% |
| Psychology | 9 | 9% |
| Neuroscience | 7 | 7% |
| Agricultural and Biological Sciences | 5 | 5% |
| Social Sciences | 5 | 5% |
| Other | 17 | 18% |
| Unknown | 24 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 June 2021.
All research outputs
#3,653,220
of 25,654,806 outputs
Outputs from ADHD Attention Deficit and Hyperactivity Disorders
#51
of 186 outputs
Outputs of similar age
#23,478
of 178,297 outputs
Outputs of similar age from ADHD Attention Deficit and Hyperactivity Disorders
#3
of 9 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 186 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 178,297 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.