| Title |
The hnRNP family: insights into their role in health and disease
|
|---|---|
| Published in |
Human Genetics, May 2016
|
| DOI | 10.1007/s00439-016-1683-5 |
| Pubmed ID | |
| Authors |
Thomas Geuens, Delphine Bouhy, Vincent Timmerman |
| Abstract |
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 24% |
| France | 2 | 8% |
| Australia | 1 | 4% |
| Colombia | 1 | 4% |
| Unknown | 15 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 23 | 92% |
| Practitioners (doctors, other healthcare professionals) | 1 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 883 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 882 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 198 | 22% |
| Student > Bachelor | 120 | 14% |
| Student > Master | 112 | 13% |
| Researcher | 90 | 10% |
| Student > Doctoral Student | 43 | 5% |
| Other | 76 | 9% |
| Unknown | 244 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 341 | 39% |
| Agricultural and Biological Sciences | 98 | 11% |
| Medicine and Dentistry | 44 | 5% |
| Neuroscience | 37 | 4% |
| Immunology and Microbiology | 20 | 2% |
| Other | 81 | 9% |
| Unknown | 262 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2023.
All research outputs
#1,387,627
of 26,017,215 outputs
Outputs from Human Genetics
#100
of 3,050 outputs
Outputs of similar age
#24,537
of 353,764 outputs
Outputs of similar age from Human Genetics
#1
of 39 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,050 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,764 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.