| Title |
PGP 9.5 distribution patterns in biopsies from early lesions of atopic dermatitis
|
|---|---|
| Published in |
Archives of Dermatological Research, June 2012
|
| DOI | 10.1007/s00403-012-1246-0 |
| Pubmed ID | |
| Authors |
Lennart Emtestam, Lena Hagströmer, Ying-Chun Dou, Karin Sartorius, Olle Johansson |
| Abstract |
Peripheral nerve fibres are often increased in lesional skin of atopic dermatitis (AD) patients. We attempted to study nerve fibre profiles, using PGP 9.5 as neuronal marker, in early AD lesions in 10 patients, as compared to non-lesional skin in the same patients and skin from healthy controls. The number of PGP 9.5-positive nerve fibre profiles was not different in the biopsies taken from normal-looking AD skin and healthy controls. The total number of PGP 9.5-positive nerve fibre profiles in the whole skin sections was higher in both the epidermis and the dermis in the group of skin biopsies taken from early lesions of AD patients. Further, the number of epidermal PGP 9.5-positive dendritic cells was increased in AD skin. It seems reasonable that PGP 9.5-positive nerve fibres and PGP 9.5-positive dendritic cells have pathological roles in AD. The findings might serve as a basis for further studies in evaluating novel diagnostic and therapeutic approaches. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 28% |
| Student > Ph. D. Student | 3 | 17% |
| Student > Master | 3 | 17% |
| Student > Bachelor | 1 | 6% |
| Unspecified | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 4 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 17% |
| Medicine and Dentistry | 3 | 17% |
| Nursing and Health Professions | 2 | 11% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Unspecified | 1 | 6% |
| Other | 2 | 11% |
| Unknown | 6 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2012.
All research outputs
#18,309,495
of 22,669,724 outputs
Outputs from Archives of Dermatological Research
#1,086
of 1,314 outputs
Outputs of similar age
#126,961
of 165,172 outputs
Outputs of similar age from Archives of Dermatological Research
#9
of 12 outputs
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So far Altmetric has tracked 1,314 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
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