Title |
Vitamin D and multiple sclerosis: a critical review and recommendations on treatment
|
---|---|
Published in |
Acta Neurologica Belgica, July 2012
|
DOI | 10.1007/s13760-012-0108-z |
Pubmed ID | |
Authors |
Alireza Faridar, Ghazaleh Eskandari, Mohammad Ali Sahraian, Alireza Minagar, Amirreza Azimi |
Abstract |
Multiple sclerosis (MS) is an immune-mediated and degenerative disease of nervous system, which affects mostly young adults. Vitamin D deficiency is a well-known environmental risk factor for MS and is considerable in terms of immediate clinical implications. In addition to its classical action on regulation of bone homeostasis, vitamin D may have a potent impact on cytokine profiles and neuro-inflammation. Given the immunomodulatory effects of vitamin D and its high rate of deficiency in MS patients, prescribing vitamin D is a remarkable issue in MS. The results from several experimental and clinical studies indicate that vitamin D supplementation may ameliorate the inflammation during the relapse phase and attenuate disease progression. We present the experimental and clinical studies, which assessed the effects of vitamin D on the pathophysiology, prevalence and management of MS. The authors also discuss current recommendations on prescription of this vitamin to MS patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 84 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 19 | 22% |
Researcher | 10 | 12% |
Student > Ph. D. Student | 10 | 12% |
Student > Bachelor | 10 | 12% |
Student > Doctoral Student | 6 | 7% |
Other | 20 | 23% |
Unknown | 11 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 33 | 38% |
Agricultural and Biological Sciences | 12 | 14% |
Nursing and Health Professions | 7 | 8% |
Neuroscience | 6 | 7% |
Social Sciences | 3 | 3% |
Other | 10 | 12% |
Unknown | 15 | 17% |