Title |
Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
|
---|---|
Published in |
BMC Cancer, July 2010
|
DOI | 10.1186/1471-2407-10-392 |
Pubmed ID | |
Authors |
Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Chang-Rok Im, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im |
Abstract |
Cinnamomum cassia bark is the outer skin of an evergreen tall tree belonging to the family Lauraceae containing several active components such as essential oils (cinnamic aldehyde and cinnamyl aldehyde), tannin, mucus and carbohydrate. They have various biological functions including anti-oxidant, anti-microbial, anti-inflammation, anti-diabetic and anti-tumor activity. Previously, we have reported that anti-cancer effect of cinnamon extracts is associated with modulation of angiogenesis and effector function of CD8+ T cells. In this study, we further identified that anti-tumor effect of cinnamon extracts is also link with enhanced pro-apoptotic activity by inhibiting the activities NFkappaB and AP1 in mouse melanoma model. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 56% |
Netherlands | 1 | 11% |
Canada | 1 | 11% |
Unknown | 2 | 22% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 195 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 34 | 17% |
Student > Ph. D. Student | 24 | 12% |
Student > Bachelor | 24 | 12% |
Researcher | 19 | 10% |
Student > Postgraduate | 10 | 5% |
Other | 35 | 18% |
Unknown | 49 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 47 | 24% |
Medicine and Dentistry | 30 | 15% |
Biochemistry, Genetics and Molecular Biology | 23 | 12% |
Chemistry | 10 | 5% |
Nursing and Health Professions | 9 | 5% |
Other | 25 | 13% |
Unknown | 51 | 26% |