| Title |
Functional regulation of monocyte-derived dendritic cells by microRNAs
|
|---|---|
| Published in |
Protein & Cell, July 2012
|
| DOI | 10.1007/s13238-012-0042-0 |
| Pubmed ID | |
| Authors |
Yifan Zhan, Li Wu |
| Abstract |
Dendritic cells (DCs) as a rare type of leukocytes play an important role in bridging the innate and adaptive immune system. A subset of DCs, monocyte-derived dendritic cells (moDCs), exists in very low numbers at steady state but become abundant in inflammatory states. These inflammation-associated DCs are potent producers of pro-inflammatory cytokines and potent inducers of T helper differentiation. They behave as a "double-edge" sword so that they not only mediate protective immunity but also immuno-pathology. It is still incompletely understood how their function is regulated. Emerging evidence indicates that microRNAs (miRNAs), as a new class of gene regulators, potently regulate the function of moDCs. Here we summarize recent progress in this area. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 32 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 30% |
| Student > Ph. D. Student | 6 | 18% |
| Student > Doctoral Student | 5 | 15% |
| Student > Master | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 2 | 6% |
| Unknown | 4 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 30% |
| Medicine and Dentistry | 5 | 15% |
| Immunology and Microbiology | 5 | 15% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Psychology | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 8 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2022.
All research outputs
#3,098,271
of 22,669,724 outputs
Outputs from Protein & Cell
#124
of 737 outputs
Outputs of similar age
#21,279
of 164,332 outputs
Outputs of similar age from Protein & Cell
#1
of 10 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 737 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done well, scoring higher than 82% of its peers.
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We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them