| Title |
The yeast Hsp70 homolog Ssb: a chaperone for general de novo protein folding and a nanny for specific intrinsically disordered protein domains
|
|---|---|
| Published in |
Current Genetics, May 2016
|
| DOI | 10.1007/s00294-016-0610-6 |
| Pubmed ID | |
| Authors |
Volker Hübscher, Kaivalya Mudholkar, Sabine Rospert |
| Abstract |
Activation of the heterotrimeric kinase SNF1 via phosphorylation of a specific residue within the α subunit is essential for the release from glucose repression in the yeast Saccharomyces cerevisiae. When glucose is available, SNF1 is maintained in the dephosphorylated, inactive state by the phosphatase Glc7-Reg1. Recent findings suggest that Bmh and Ssb combine their unique client-binding properties to interact with the regulatory region of the SNF1 α subunit and by that stabilize a conformation of SNF1, which is accessible for Glc7-Reg1-dependent dephosphorylation. Together, the 14-3-3 protein Bmh and the Hsp70 homolog Ssb comprise a novel chaperone module, which is required to maintain proper glucose repression in the yeast S. cerevisiae. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 33% |
| Student > Master | 4 | 15% |
| Student > Bachelor | 3 | 11% |
| Researcher | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Other | 0 | 0% |
| Unknown | 6 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 44% |
| Agricultural and Biological Sciences | 6 | 22% |
| Immunology and Microbiology | 1 | 4% |
| Chemistry | 1 | 4% |
| Unknown | 7 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2016.
All research outputs
#17,806,995
of 22,875,477 outputs
Outputs from Current Genetics
#929
of 1,203 outputs
Outputs of similar age
#238,425
of 337,040 outputs
Outputs of similar age from Current Genetics
#18
of 27 outputs
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