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CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex*

Overview of attention for article published in Journal of Biological Chemistry, May 2016
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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18 news outlets
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3 X users

Citations

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61 Dimensions

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76 Mendeley
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Title
CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex*
Published in
Journal of Biological Chemistry, May 2016
DOI 10.1074/jbc.m115.707018
Pubmed ID
Authors

Jason K K Low, Sarah R Webb, Ana P G Silva, Hinnerk Saathoff, Daniel P Ryan, Mario Torrado, Mattias Brofelth, Benjamin L Parker, Nicholas E Shepherd, Joel P Mackay

Abstract

Chromatin remodeling enzymes act to dynamically regulate gene accessibility. In many cases, these enzymes function as large multi-component complexes that, in general, comprise a central ATP-dependent Snf2-family helicase that is decorated with a variable number of regulatory subunits. The Nucleosome Remodeling and Deacetylase complex (NuRD), which is essential for normal development in higher organisms, is one such macromolecular machine. The NuRD complex comprises approximately 10 subunits, including the histone deacetylases 1 and 2 (HDAC1 and HDAC2), and is defined by the presence of a CHD-family remodeling enzyme - most commonly Chromodomain Helicase DNA-binding protein 4 (CHD4). The existing paradigm holds that CHD4 acts as the central hub upon which the complex is built. We show here that this paradigm does not, in fact, hold and that CHD4 is only a peripheral and dynamic component of the NuRD complex. A complex lacking CHD4 that has HDAC activity can exist as a stable species in cells. The addition of recombinant CHD4 to this Nucleosome Deacetylase (NuDe) complex reconstitutes a NuRD complex with nucleosome remodeling activity. These data are an important step towards understanding the architecture of the NuRD complex.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 1%
Unknown 75 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 26%
Researcher 9 12%
Student > Bachelor 9 12%
Student > Doctoral Student 7 9%
Student > Master 7 9%
Other 11 14%
Unknown 13 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 30 39%
Agricultural and Biological Sciences 18 24%
Medicine and Dentistry 7 9%
Chemistry 4 5%
Neuroscience 1 1%
Other 1 1%
Unknown 15 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 138. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2016.
All research outputs
#299,633
of 25,394,764 outputs
Outputs from Journal of Biological Chemistry
#75
of 85,270 outputs
Outputs of similar age
#5,888
of 353,126 outputs
Outputs of similar age from Journal of Biological Chemistry
#2
of 407 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85,270 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,126 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 407 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.