| Title |
San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats
|
|---|---|
| Published in |
BMC Complementary Medicine and Therapies, May 2016
|
| DOI | 10.1186/s12906-016-1127-8 |
| Pubmed ID | |
| Authors |
Yu-Lan Yeh, Wei-Jen Ting, Wei-Wen Kuo, Hsi-Hsien Hsu, Yueh-Min Lin, Chia-Yao Shen, Chung-Ho Chang, Viswanadha Vijaya Padma, Yuhsin Tsai, Chih-Yang Huang |
| Abstract |
San Huang Shel Shin Tang (SHSST) is a traditional herbal decoction used as a hepato-protective agent and is composed of Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (2:1:1 w/w). Beta-cyclodextrin (β-CD) modification may potentially increase the solubility and spectral properties of SHSST. In this research, the hepato-protective effects of unmodified SHSST, β-CD modified SHSST complex (SHSSTc) and silymarin were evaluated in carbon tetrachloride (CCl4) induced acute hepatotoxicity in rats. SHHSTc (40 mg/kg/day) and silymarin (100 mg/kg/day) both decreased the CCl4-induced cirrhosis pathway-related transforming growth factor beta (TGF-β) and apoptosis pathway-related caspase-8 protein expressions, but SHSST (40 mg/kg/day) did not reduce TGF-β and caspase-8 significantly . Moreover, SHHSTc (40 mg/kg/day) enhanced the activation of insulin-like growth factor 1 receptor (IGF1R) mediated survival pathway than the silymarin (100 mg/kg/day) to protect the liver from damage induced by CCl4. β-CD modification promotes hepato-protective effects of SHSST and reduces the required-dosage of the SHSST. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 6% |
| Unknown | 17 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 6% |
| Lecturer > Senior Lecturer | 1 | 6% |
| Librarian | 1 | 6% |
| Other | 1 | 6% |
| Student > Bachelor | 1 | 6% |
| Other | 4 | 22% |
| Unknown | 9 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 3 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
| Unspecified | 1 | 6% |
| Chemistry | 1 | 6% |
| Unknown | 11 | 61% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2016.
All research outputs
#20,330,976
of 22,875,477 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,984
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Outputs of similar age
#290,742
of 338,302 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#48
of 58 outputs
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