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Mendeley readers
Attention Score in Context
| Title |
Encapsulation of biophenolic phytochemical EGCG within lipid nanoparticles enhances its stability and cytotoxicity against cancer
|
|---|---|
| Published in |
Chemistry & Physics of Lipids, May 2016
|
| DOI | 10.1016/j.chemphyslip.2016.05.006 |
| Pubmed ID | |
| Authors |
Rasika Radhakrishnan, Hitesh Kulhari, Deep Pooja, Sagarika Gudem, Suresh Bhargava, Ravi Shukla, Ramakrishna Sistla |
| Abstract |
Epigallocatechin gallate (EGCG), a green tea polyphenolic catechin, has been known to possess a variety of beneficial biological activities. The anti-cancer activity of EGCG in many cancer cell lines is well documented. However, the use of EGCG in modern therapeutics is limited due to its poor bioavailability and limited stability at physiological pH. In this study, we have investigated the stability profiles of EGCG in aqueous solutions using UV-Visible spectroscopy. Stability results showed very low stability profile of EGCG at physiological conditions with rapid degradation under alkaline conditions. Therefore, we have encapsulated EGCG in solid lipid nanoparticles to increase its stability and evaluated for anticancer activity. The lipid core of nanoparticles not only provides an additional structural reinforcement to the nanoparticle assembly, but also makes it biologically compatible, thereby enabling a stealth vehicle for efficient drug delivery. EGCG loaded nanoparticles (EGCG-SLN) were characterized using dynamic light scattering, Fourier transform infrared spectroscopy and differential scanning calorimetry. EGCG and EGCG-SLN were evaluated for their anticancer activities by cellular proliferation. The cytotoxicity of EGCG-SLN was found to be 8.1 times higher against MDA-MB 231 human breast cancer cells and 3.8 times higher against DU-145 human prostate cancer cells than that of the pure EGCG. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | <1% |
| Unknown | 130 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 13% |
| Researcher | 14 | 11% |
| Student > Master | 13 | 10% |
| Student > Bachelor | 12 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Other | 22 | 17% |
| Unknown | 44 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 21 | 16% |
| Biochemistry, Genetics and Molecular Biology | 12 | 9% |
| Chemistry | 12 | 9% |
| Agricultural and Biological Sciences | 12 | 9% |
| Medicine and Dentistry | 5 | 4% |
| Other | 16 | 12% |
| Unknown | 53 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2016.
All research outputs
#22,778,604
of 25,394,764 outputs
Outputs from Chemistry & Physics of Lipids
#968
of 1,167 outputs
Outputs of similar age
#304,711
of 348,872 outputs
Outputs of similar age from Chemistry & Physics of Lipids
#10
of 10 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,167 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,872 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one.