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Antibody‐Targeted Drug Delivery to Injured Arteries Using Layered Double Hydroxide Nanoparticles

Overview of attention for article published in Advanced Healthcare Materials, July 2012
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41 Mendeley
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Title
Antibody‐Targeted Drug Delivery to Injured Arteries Using Layered Double Hydroxide Nanoparticles
Published in
Advanced Healthcare Materials, July 2012
DOI 10.1002/adhm.201200069
Pubmed ID
Authors

Zi Gu, Barbara E. Rolfe, Zhi Ping Xu, Julie H. Campbell, G. Q. Lu, Anita C. Thomas

Abstract

Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 2%
Unknown 40 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 27%
Student > Master 5 12%
Researcher 4 10%
Lecturer 3 7%
Student > Doctoral Student 3 7%
Other 10 24%
Unknown 5 12%
Readers by discipline Count As %
Chemistry 7 17%
Agricultural and Biological Sciences 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 5 12%
Engineering 5 12%
Chemical Engineering 3 7%
Other 7 17%
Unknown 9 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2012.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Advanced Healthcare Materials
#2,549
of 2,904 outputs
Outputs of similar age
#160,924
of 177,929 outputs
Outputs of similar age from Advanced Healthcare Materials
#27
of 40 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,904 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 177,929 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.