| Title |
Pleiotropic Effects of Neurotransmission during Development: Modulators of Modularity
|
|---|---|
| Published in |
Journal of Autism and Developmental Disorders, July 2008
|
| DOI | 10.1007/s10803-008-0624-0 |
| Pubmed ID | |
| Authors |
Barbara L. Thompson, Gregg D. Stanwood |
| Abstract |
The formation and function of the mammalian cerebral cortex relies on the complex interplay of a variety of genetic and environmental factors through protracted periods of gestational and postnatal development. Biogenic amine systems are important neuromodulators, both in the adult nervous system, and during critical epochs of brain development. Abnormalities in developmental programming likely contribute to developmental delays and multiple neurological and psychiatric disorders, often with symptom onset much later than the actual induction of pathology. We review several genetic and pharmacological models of dopamine, norepinephrine and serotonin modulation during development, each of which produces permanent changes in cerebral cortical structure and function. These models clearly illustrate the ability of these neurotransmitters to function beyond their classic roles and show their involvement in the development and modulation of fine brain circuitry that is sensitive to numerous effectors. Furthermore, these studies demonstrate the need to consider not only gene by environment interactions, but also gene by environment by developmental time interactions. |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Croatia | 1 | 3% |
| Netherlands | 1 | 3% |
| Belgium | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 31 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 20% |
| Student > Master | 5 | 14% |
| Student > Doctoral Student | 4 | 11% |
| Other | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 5 | 14% |
| Unknown | 8 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 23% |
| Neuroscience | 5 | 14% |
| Medicine and Dentistry | 4 | 11% |
| Psychology | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 7 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 July 2012.
All research outputs
#21,376,200
of 23,867,274 outputs
Outputs from Journal of Autism and Developmental Disorders
#4,711
of 5,240 outputs
Outputs of similar age
#80,797
of 83,964 outputs
Outputs of similar age from Journal of Autism and Developmental Disorders
#23
of 25 outputs
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