| Title |
Transcription Factor NF-κB: An Update on Intervention Strategies
|
|---|---|
| Published in |
Archivum Immunologiae et Therapiae Experimentalis, May 2016
|
| DOI | 10.1007/s00005-016-0405-y |
| Pubmed ID | |
| Authors |
Arvind Panday, Maria Eugenia Inda, Prathyusha Bagam, Malaya K. Sahoo, Diana Osorio, Sanjay Batra |
| Abstract |
The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 94 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 17% |
| Researcher | 15 | 16% |
| Student > Ph. D. Student | 14 | 15% |
| Student > Bachelor | 13 | 14% |
| Student > Doctoral Student | 10 | 11% |
| Other | 10 | 11% |
| Unknown | 16 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 23% |
| Biochemistry, Genetics and Molecular Biology | 20 | 21% |
| Agricultural and Biological Sciences | 9 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Immunology and Microbiology | 4 | 4% |
| Other | 10 | 11% |
| Unknown | 24 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2017.
All research outputs
#17,286,379
of 25,374,917 outputs
Outputs from Archivum Immunologiae et Therapiae Experimentalis
#264
of 406 outputs
Outputs of similar age
#224,694
of 352,949 outputs
Outputs of similar age from Archivum Immunologiae et Therapiae Experimentalis
#7
of 11 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 406 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,949 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.