Title |
Keloids: The paradigm of skin fibrosis — Pathomechanisms and treatment
|
---|---|
Published in |
Matrix Biology, February 2016
|
DOI | 10.1016/j.matbio.2016.01.013 |
Pubmed ID | |
Authors |
Jonathan P. Andrews, Jaana Marttala, Edward Macarak, Joel Rosenbloom, Jouni Uitto |
Abstract |
Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix (ECM) components, particularly collagen, result from excessive expression of growth factors and cytokines. The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals. Several treatment methods for keloids exist, including the combination therapy of surgical incision followed by intralesional steroid therapy, however, they have high recurrence rate regardless of the current treatment method. Improved understanding of the pathomechanisms leading to keloid formation will hopefully identify pathways that serve as specific targets to improve therapy for this devastating, currently intractable, disorder. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Unknown | 222 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 29 | 13% |
Student > Ph. D. Student | 25 | 11% |
Student > Master | 24 | 11% |
Student > Postgraduate | 20 | 9% |
Researcher | 18 | 8% |
Other | 45 | 20% |
Unknown | 63 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 72 | 32% |
Biochemistry, Genetics and Molecular Biology | 30 | 13% |
Agricultural and Biological Sciences | 15 | 7% |
Engineering | 6 | 3% |
Nursing and Health Professions | 4 | 2% |
Other | 27 | 12% |
Unknown | 70 | 31% |