| Title |
Characterization of antiproliferative potential and biological targets of a copper compound containing 4′-phenyl terpyridine
|
|---|---|
| Published in |
JBIC Journal of Biological Inorganic Chemistry, June 2015
|
| DOI | 10.1007/s00775-015-1277-z |
| Pubmed ID | |
| Authors |
Ana Soraia Mendo, Sara Figueiredo, Catarina Roma-Rodrigues, Paula A. Videira, Zhen Ma, Mário Diniz, Miguel Larguinho, Pedro M. Costa, João C. Lima, Armando J. L. Pombeiro, Pedro V. Baptista, Alexandra R. Fernandes |
| Abstract |
Several copper complexes have been assessed as anti-tumor agents against cancer cells. In this work, a copper compound [Cu(H2O){OS(CH3)2}L](NO3)2 incorporating the ligand 4'-phenyl-terpyridine antiproliferative activity against human colorectal, hepatocellular carcinomas and breast adenocarcinoma cell lines was determined, demonstrating high cytotoxicity. The compound is able to induce apoptosis and a slight delay in cancer cell cycle progression, probably by its interaction with DNA and induction of double-strand pDNA cleavage, which is enhanced by oxidative mechanisms. Moreover, proteomic studies indicate that the compound induces alterations in proteins involved in cytoskeleton maintenance, cell cycle progression and apoptosis, corroborating its antiproliferative potential. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Unknown | 42 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 16% |
| Student > Bachelor | 7 | 16% |
| Researcher | 6 | 14% |
| Other | 4 | 9% |
| Student > Ph. D. Student | 4 | 9% |
| Other | 8 | 19% |
| Unknown | 7 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Agricultural and Biological Sciences | 7 | 16% |
| Chemistry | 7 | 16% |
| Medicine and Dentistry | 3 | 7% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 7% |
| Unknown | 12 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2016.
All research outputs
#21,180,380
of 23,842,189 outputs
Outputs from JBIC Journal of Biological Inorganic Chemistry
#590
of 664 outputs
Outputs of similar age
#201,220
of 241,477 outputs
Outputs of similar age from JBIC Journal of Biological Inorganic Chemistry
#5
of 7 outputs
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So far Altmetric has tracked 664 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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