| Title |
Etiology of Crohn’s disease: many roads lead to autophagy
|
|---|---|
| Published in |
Journal of Molecular Medicine, July 2012
|
| DOI | 10.1007/s00109-012-0934-8 |
| Pubmed ID | |
| Authors |
Pierre Lapaquette, Patrick Brest, Paul Hofman, Arlette Darfeuille-Michaud |
| Abstract |
Crohn's disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn's disease is influenced by common variants at many loci. Genetic studies have emphasized the role of host susceptibility in inflammatory bowel disease onset with the identification of about 100 risk loci, most of which encode proteins involved in immunity, host defense against microbes, and gut homeostasis. In this review, we focus on susceptibility genes related to autophagy in the etiology of Crohn's disease (CD) and their complex interplay with the gut microbiota, as illustrated by the relationship between immunity-related GTPase family M alleles, microRNA, and xenophagy in CD predisposition. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Ireland | 1 | 1% |
| Germany | 1 | 1% |
| Denmark | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 70 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 13 | 17% |
| Researcher | 12 | 16% |
| Student > Master | 11 | 14% |
| Professor > Associate Professor | 7 | 9% |
| Other | 10 | 13% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 26% |
| Medicine and Dentistry | 16 | 21% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Immunology and Microbiology | 10 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2012.
All research outputs
#20,139,119
of 25,654,806 outputs
Outputs from Journal of Molecular Medicine
#1,786
of 2,146 outputs
Outputs of similar age
#135,351
of 178,934 outputs
Outputs of similar age from Journal of Molecular Medicine
#11
of 15 outputs
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