| Title |
Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism
|
|---|---|
| Published in |
European Journal of Nutrition, July 2012
|
| DOI | 10.1007/s00394-012-0415-4 |
| Pubmed ID | |
| Authors |
Yan Campbell, Mary L. Fantacone, Adrian F. Gombart |
| Abstract |
Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense, and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs bind lipopolysaccharides, act as chemoattractants for immune cells and bind to cellular receptors and modulate the expression of cytokines and chemokines. These additional biological activities may explain the role of AMPs in inflammatory diseases and cancer. Modulating the endogenous expression of AMPs offers potential therapeutic treatments for infection and disease. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| Spain | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 116 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 22% |
| Researcher | 20 | 17% |
| Student > Bachelor | 15 | 13% |
| Student > Master | 10 | 9% |
| Student > Postgraduate | 6 | 5% |
| Other | 15 | 13% |
| Unknown | 25 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 26% |
| Medicine and Dentistry | 21 | 18% |
| Biochemistry, Genetics and Molecular Biology | 17 | 15% |
| Immunology and Microbiology | 6 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 26 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#2,345,658
of 23,943,619 outputs
Outputs from European Journal of Nutrition
#576
of 2,494 outputs
Outputs of similar age
#14,766
of 166,625 outputs
Outputs of similar age from European Journal of Nutrition
#14
of 42 outputs
Altmetric has tracked 23,943,619 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,494 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 166,625 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.