| Title |
Testosterone supplementation and body composition: results from a meta-analysis of observational studies
|
|---|---|
| Published in |
Journal of Endocrinological Investigation, May 2016
|
| DOI | 10.1007/s40618-016-0480-2 |
| Pubmed ID | |
| Authors |
G. Corona, V. A. Giagulli, E. Maseroli, L. Vignozzi, A. Aversa, M. Zitzmann, F. Saad, E. Mannucci, M. Maggi |
| Abstract |
The concept of testosterone (T) supplementation (TS) as a new anti-obesity medication in men with testosterone deficiency syndrome (TDS) is emerging. Data from placebo-controlled trials are more conflicting. The aim of this study is to systematically review and meta-analyze available observational and register studies reporting data on body composition in studies on TS in TDS. An extensive MEDLINE, Embase, and Cochrane search was performed including the following words: "testosterone" and "body composition." All observational studies comparing the effect of TS on body weight and other body composition and metabolic endpoints were considered. Out of 824 retrieved articles, 32 were included in the study enrolling 4513 patients (mean age 51.7 ± 6.1 years). TS was associated with a time-dependent reduction in body weight and waist circumference (WC). The estimated weight loss and WC reduction at 24 months were -3.50 [-5.21; -1.80] kg and -6.23 [-7.94; -4.76] cm, respectively. TS was also associated with a significant reduction in fat and with an increase in lean mass as well as with a reduction in fasting glycemia and insulin resistance. In addition, an improvement of lipid profile (reduction in total cholesterol as well as of triglyceride levels and an improvement in HDL cholesterol levels) and in both systolic and diastolic blood pressure was observed. Present data support the view of a positive effect of TS on body composition and on glucose and lipid metabolism. In addition, a significant effect on body weight loss was observed, which should be confirmed by a specifically designed RCT. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 17% |
| Spain | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 50% |
| Practitioners (doctors, other healthcare professionals) | 2 | 33% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 111 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 13% |
| Student > Ph. D. Student | 13 | 12% |
| Student > Master | 12 | 11% |
| Researcher | 11 | 10% |
| Other | 9 | 8% |
| Other | 25 | 23% |
| Unknown | 27 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 41% |
| Biochemistry, Genetics and Molecular Biology | 12 | 11% |
| Nursing and Health Professions | 6 | 5% |
| Agricultural and Biological Sciences | 6 | 5% |
| Social Sciences | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 30 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2022.
All research outputs
#1,697,889
of 25,374,647 outputs
Outputs from Journal of Endocrinological Investigation
#62
of 1,622 outputs
Outputs of similar age
#30,136
of 352,984 outputs
Outputs of similar age from Journal of Endocrinological Investigation
#2
of 27 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,622 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.