Title |
Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
|
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Published in |
Journal of Natural Products, May 2016
|
DOI | 10.1021/acs.jnatprod.5b00961 |
Pubmed ID | |
Authors |
Patima Phainuphong, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Kawitsara Bowornwiriyapan, Chatchai Muanprasat, Chutima Srimaroeng, Acharaporn Duangjai, Jariya Sakayaroj |
Abstract |
Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC50 value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC50 value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC50 value of 2.2 μM. |
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Mendeley readers
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Student > Bachelor | 7 | 16% |
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Unknown | 10 | 23% |
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