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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
|
|---|---|
| Published in |
Journal of Natural Products, May 2016
|
| DOI | 10.1021/acs.jnatprod.5b00961 |
| Pubmed ID | |
| Authors |
Patima Phainuphong, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Kawitsara Bowornwiriyapan, Chatchai Muanprasat, Chutima Srimaroeng, Acharaporn Duangjai, Jariya Sakayaroj |
| Abstract |
Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC50 value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC50 value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC50 value of 2.2 μM. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 42 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 20% |
| Student > Bachelor | 7 | 16% |
| Researcher | 5 | 11% |
| Lecturer | 4 | 9% |
| Student > Master | 3 | 7% |
| Other | 6 | 14% |
| Unknown | 10 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 23% |
| Chemistry | 7 | 16% |
| Agricultural and Biological Sciences | 6 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Immunology and Microbiology | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 13 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 September 2021.
All research outputs
#15,377,214
of 22,876,619 outputs
Outputs from Journal of Natural Products
#3,921
of 4,981 outputs
Outputs of similar age
#210,149
of 337,044 outputs
Outputs of similar age from Journal of Natural Products
#33
of 55 outputs
Altmetric has tracked 22,876,619 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,981 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,044 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.