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X Demographics
Mendeley readers
Attention Score in Context
| Title |
MiniCORVET is a Vps8-containing early endosomal tether in Drosophila
|
|---|---|
| Published in |
eLife, June 2016
|
| DOI | 10.7554/elife.14226 |
| Pubmed ID | |
| Authors |
Péter Lőrincz, Zsolt Lakatos, Ágnes Varga, Tamás Maruzs, Zsófia Simon-Vecsei, Zsuzsanna Darula, Péter Benkő, Gábor Csordás, Mónika Lippai, István Andó, Krisztina Hegedűs, Katalin F Medzihradszky, Szabolcs Takáts, Gábor Juhász |
| Abstract |
Yeast studies identified two heterohexameric tethering complexes, which consist of 4 shared (Vps11, Vps16, Vps18 and Vps33) and 2 specific subunits: Vps3 and Vps8 (CORVET) versus Vps39 and Vps41 (HOPS). CORVET is an early and HOPS is a late endosomal tether. The function of HOPS is well known in animal cells, while CORVET is poorly characterized. Here we show that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog. We find that Vps8 forms a complex and acts together with Vps16A, Dor/Vps18 and Car/Vps33A, and loss of any of these proteins leads to fragmentation of endosomes. Surprisingly, Vps11 deletion causes enlargement of endosomes, similar to loss of the HOPS-specific subunits Vps39 and Lt/Vps41. We thus identify a 4 subunit-containing miniCORVET complex as an unconventional early endosomal tether in Drosophila. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 33% |
| United States | 1 | 33% |
| France | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 75 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Student > Master | 11 | 14% |
| Researcher | 10 | 13% |
| Student > Doctoral Student | 8 | 10% |
| Student > Bachelor | 6 | 8% |
| Other | 9 | 12% |
| Unknown | 16 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 27 | 35% |
| Agricultural and Biological Sciences | 26 | 33% |
| Medicine and Dentistry | 4 | 5% |
| Neuroscience | 2 | 3% |
| Immunology and Microbiology | 1 | 1% |
| Other | 2 | 3% |
| Unknown | 16 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2016.
All research outputs
#14,431,072
of 23,577,654 outputs
Outputs from eLife
#12,302
of 14,362 outputs
Outputs of similar age
#187,541
of 341,133 outputs
Outputs of similar age from eLife
#225
of 285 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,362 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,133 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 285 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.