| Title |
Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions
|
|---|---|
| Published in |
Brain Structure and Function, June 2016
|
| DOI | 10.1007/s00429-016-1239-4 |
| Pubmed ID | |
| Authors |
Xin Di, Jia Huang, Bharat B. Biswal |
| Abstract |
Understanding functional connectivity of the amygdala with other brain regions, especially task modulated connectivity, is a critical step toward understanding the role of the amygdala in emotional processes and the interactions between emotion and cognition. The present study performed coordinate-based meta-analysis on studies of task modulated connectivity of the amygdala which used psychophysiological interaction (PPI) analysis. We first analyzed 49 PPI studies on different types of tasks using activation likelihood estimation (ALE) meta-analysis. Widespread cortical and subcortical regions showed consistent task modulated connectivity with the amygdala, including the medial frontal cortex, bilateral insula, anterior cingulate, fusiform gyrus, parahippocampal gyrus, thalamus, and basal ganglia. These regions were in general overlapped with those showed coactivations with the amygdala, suggesting that these regions and amygdala are not only activated together, but also show different levels of interactions during tasks. Further analyses with subsets of PPI studies revealed task specific functional connectivities with the amygdala that were modulated by fear processing, face processing, and emotion regulation. These results suggest a dynamic modulation of connectivity upon task demands, and provide new insights on the functions of the amygdala in different affective and cognitive processes. The meta-analytic approach on PPI studies may offer a framework toward systematical examinations of task modulated connectivity. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 26% |
| Canada | 2 | 11% |
| United Kingdom | 1 | 5% |
| Iraq | 1 | 5% |
| Germany | 1 | 5% |
| China | 1 | 5% |
| Chile | 1 | 5% |
| Finland | 1 | 5% |
| Unknown | 6 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 53% |
| Scientists | 7 | 37% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 96 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 23% |
| Researcher | 17 | 18% |
| Student > Master | 12 | 12% |
| Student > Doctoral Student | 11 | 11% |
| Student > Bachelor | 8 | 8% |
| Other | 11 | 11% |
| Unknown | 16 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 45 | 46% |
| Neuroscience | 12 | 12% |
| Medicine and Dentistry | 4 | 4% |
| Agricultural and Biological Sciences | 3 | 3% |
| Biochemistry, Genetics and Molecular Biology | 3 | 3% |
| Other | 4 | 4% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2018.
All research outputs
#2,852,827
of 24,340,143 outputs
Outputs from Brain Structure and Function
#197
of 1,724 outputs
Outputs of similar age
#49,296
of 345,241 outputs
Outputs of similar age from Brain Structure and Function
#8
of 34 outputs
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